If humanity was rooted in a supernaturally accepted view of morality, then a clean separation between church and state would seem appropriate. The framers of the Constitution desired boundaries to protect their religious beliefs from government intrusion (Church/State). Of course today, the loudest voices are focused the other way around, desiring to isolate the government from the supposed tyranny of a Biblical Christian worldview (Secularization is good for American democracy).
As Biblical Christians, we need to hold fast to our faith (Hebrews 10:23), yet show grace and love to those who oppose our worldview (1 Corinthians 13). Scripture is clear that if we are in the end-times we need to be prepared and, if we are not, the pendulum will eventually swing back toward a more peaceful expression of our differences.